AMSTERDAM · EST. 2026
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LONGEVITYGRADE CMOSTLY PRECLINICAL

MOTS-c

Mitochondrial-derived peptide; AMPK activation

A mitochondrial-derived peptide that activates AMPK and is described in the literature as an exercise mimetic. Research is almost entirely preclinical, with metabolic and healthspan endpoints.

ALSO KNOWN AS Mitochondrial ORF of the 12S rRNA type-c
REGULATORY STATUS · RESEARCH COMPOUND

Research compound — not approved for human use. Compounds in this category have not been approved for human use; availability is typically restricted to laboratory research.

§ EVIDENCE BASE
246
PUBLICATIONS
indexed in PubMed
5
REGISTERED TRIALS
listing it as an intervention
1
PHASE 2–4 TRIALS
reached later-stage testing
MECHANISMMitochondrial-derived peptide; AMPK activation
CATEGORYLongevity
EVIDENCE GRADEC — Mostly preclinical
STATUSResearch compound — not approved for human use
COUNTS RETRIEVED2026-07-23 · re-run the PubMed query
§ RELATED COMPOUNDS
LONGEVITYD
Epitalon
Tetrapeptide; telomerase and pineal regulation (proposed)
NOT MEDICAL ADVICE

This page summarises how much a compound has been studied. A high publication count is not evidence that something works, is safe, or is legal to obtain where you live. Consult a qualified healthcare provider before acting on anything here.

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