AMSTERDAM · EST. 2026
Onpeps
PEPTIDE DECISION INTELLIGENCE
Subscribe
← PEPTIDE LIBRARY
METABOLICGRADE ASTRONG HUMAN EVIDENCE

Semaglutide

GLP-1 receptor agonist

A long-acting GLP-1 receptor agonist given once weekly. It slows gastric emptying and acts on hypothalamic appetite signalling, and it carries the deepest clinical trial record of any peptide used for weight management.

ALSO KNOWN AS Ozempic · Wegovy · Rybelsus
REGULATORY STATUS · FDA-APPROVED

FDA-approved (Ozempic, Wegovy, Rybelsus).

§ EVIDENCE BASE
5,214
PUBLICATIONS
indexed in PubMed
719
REGISTERED TRIALS
listing it as an intervention
400
PHASE 2–4 TRIALS
reached later-stage testing
MECHANISMGLP-1 receptor agonist
CATEGORYMetabolic
EVIDENCE GRADEA — Strong human evidence
STATUSFDA-approved (Ozempic, Wegovy, Rybelsus)
TYPICAL RECONSTITUTION5 mg vial + 2 mL BAC water
ROUTESubcutaneous — abdomen, thigh or upper arm
COUNTS RETRIEVED2026-07-23 · re-run the PubMed query
§ DOCUMENTED DOSING
Weeks 1–40.25 mg once weekly
Weeks 5–80.5 mg once weekly
Weeks 9–121.0 mg once weekly
Maintenanceup to 2.0–2.4 mg once weekly

Ranges compiled from published protocols, not a clinical guideline. Convert a dose into syringe units with the dosage calculator.

§ RELATED COMPOUNDS
METABOLICA
Tirzepatide
Dual GIP / GLP-1 receptor agonist
METABOLICC
Retatrutide
Triple GIP / GLP-1 / glucagon receptor agonist
METABOLICD
AOD-9604
hGH fragment 176-191; lipolytic activity (proposed)
NOT MEDICAL ADVICE

This page summarises how much a compound has been studied. A high publication count is not evidence that something works, is safe, or is legal to obtain where you live. Consult a qualified healthcare provider before acting on anything here.

THE WEEKLY BRIEF

Peptide intelligence, every Monday.

One concise email: the newest research, evidence updates, and quality signals — no hype, no spam.

Onpeps

Our mission is to make peptide research clear, credible, and usable for people who refuse to rely on hype.

EXPLORE
FOLLOW
PEPTIDE INFORMATION YOU CAN VERIFY© 2026 ONPEPS · AMSTERDAM, NETHERLANDS · NOT MEDICAL ADVICE