AMSTERDAM · EST. 2026
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METABOLICGRADE CMOSTLY PRECLINICAL

Retatrutide

Triple GIP / GLP-1 / glucagon receptor agonist

An investigational triple agonist adding glucagon-receptor activity to the GIP/GLP-1 mechanism. Trial results to date report the largest average weight reduction of the class, but it is not approved and is not legally available.

ALSO KNOWN AS LY3437943
REGULATORY STATUS · INVESTIGATIONAL

Investigational — in Phase 3 trials, not approved. Compounds in this category have not been approved for human use; availability is typically restricted to laboratory research.

§ EVIDENCE BASE
158
PUBLICATIONS
indexed in PubMed
33
REGISTERED TRIALS
listing it as an intervention
18
PHASE 2–4 TRIALS
reached later-stage testing
MECHANISMTriple GIP / GLP-1 / glucagon receptor agonist
CATEGORYMetabolic
EVIDENCE GRADEC — Mostly preclinical
STATUSInvestigational — in Phase 3 trials, not approved
TYPICAL RECONSTITUTIONResearch use only — not commercially available
ROUTESubcutaneous (in trials)
COUNTS RETRIEVED2026-07-23 · re-run the PubMed query
§ DOCUMENTED DOSING
Trial start1–2 mg once weekly
Titrationstepwise every 2–4 weeks
Studied dosesup to 12 mg once weekly

Ranges compiled from published protocols, not a clinical guideline. Convert a dose into syringe units with the dosage calculator.

§ RELATED COMPOUNDS
METABOLICA
Semaglutide
GLP-1 receptor agonist
METABOLICA
Tirzepatide
Dual GIP / GLP-1 receptor agonist
METABOLICD
AOD-9604
hGH fragment 176-191; lipolytic activity (proposed)
NOT MEDICAL ADVICE

This page summarises how much a compound has been studied. A high publication count is not evidence that something works, is safe, or is legal to obtain where you live. Consult a qualified healthcare provider before acting on anything here.

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