AMSTERDAM · EST. 2026
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METABOLICGRADE ASTRONG HUMAN EVIDENCE

Tirzepatide

Dual GIP / GLP-1 receptor agonist

A dual agonist hitting both the GIP and GLP-1 receptors. Head-to-head trials show greater average weight reduction than single-agonist GLP-1s, at the cost of a similar gastrointestinal side-effect profile.

ALSO KNOWN AS Mounjaro · Zepbound
REGULATORY STATUS · FDA-APPROVED

FDA-approved (Mounjaro, Zepbound).

§ EVIDENCE BASE
2,296
PUBLICATIONS
indexed in PubMed
264
REGISTERED TRIALS
listing it as an intervention
161
PHASE 2–4 TRIALS
reached later-stage testing
MECHANISMDual GIP / GLP-1 receptor agonist
CATEGORYMetabolic
EVIDENCE GRADEA — Strong human evidence
STATUSFDA-approved (Mounjaro, Zepbound)
TYPICAL RECONSTITUTION10 mg vial + 2 mL BAC water
ROUTESubcutaneous — abdomen, thigh or upper arm
COUNTS RETRIEVED2026-07-23 · re-run the PubMed query
§ DOCUMENTED DOSING
Weeks 1–42.5 mg once weekly
Weeks 5–85 mg once weekly
Then titrate7.5 → 10 → 12.5 mg as tolerated
Maximum15 mg once weekly

Ranges compiled from published protocols, not a clinical guideline. Convert a dose into syringe units with the dosage calculator.

§ RELATED COMPOUNDS
METABOLICA
Semaglutide
GLP-1 receptor agonist
METABOLICC
Retatrutide
Triple GIP / GLP-1 / glucagon receptor agonist
METABOLICD
AOD-9604
hGH fragment 176-191; lipolytic activity (proposed)
NOT MEDICAL ADVICE

This page summarises how much a compound has been studied. A high publication count is not evidence that something works, is safe, or is legal to obtain where you live. Consult a qualified healthcare provider before acting on anything here.

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